A review on peptide-targeted nanoparticles

We are proud to highlight a comprehensive review co-first authored by our recent PhD graduates, Valeria Sidorenko and Allan Tobi, published in the Journal of Controlled Release (PMID: 40925419, DOI: 10.1016/j.jconrel.2025.114195).

The review focuses on tumor-homing peptides as a strategy to improve nanoparticle drug delivery to solid tumors. While traditional nanoparticles face barriers within the tumor microenvironment, tumor-homing and tumor-penetrating peptides allow precise targeting of tumor vasculature and deep tissue penetration, enhancing drug accumulation and therapeutic outcomes while reducing off-target effects.

This work builds on years of research in our lab on precision-targeted nanoparticles and highlights the potential of peptide-guided strategies to overcome key challenges in cancer therapy.

Authors: Valeria Sidorenko, Allan Tobi, Kazuki N. Sugahara, Tambet Teesalu
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